Nocturnal Hypoxemia as a Co-Determinant of Sleepiness in Patients with Obstructive Sleep Apnea

Askin Uysal, MD1, Cesar Liendo, MD1,2, Chad Paxson, MD1, Paul Kim, PhD1, David E. McCarty, MD 1, Andrew L. Chesson, Jr., MD1, Andrew A. Marino, PhD1
1Division of Sleep Medicine, Department of Neurology, LSU Health Sciences Center, Shreveport, LA
2Overton Brooks VA Medical Center, Shreveport, LA

Presented at the 26th Annual Meeting of the Associated Professional Sleep Societies, Boston, MS, June, 2012


The association between nocturnal hypoxemia and subjective sleepiness was studied in 200 recently diagnosed OSA patients (AHI>15).

Four standard hypoxemia measures were extracted from the pulse-oximetry signal, and their linear correlations (individually and in combination) with sleepiness were determined by discriminant and AUROC analyses.

Average ODI and P90 were greater in sleepy patients (Epworth ≥10). Even so, the correlation coefficients for all possible combinations of the hypoxemia measures were low (<0.3), and resulted in low AUROC values (≤0.62).

Nocturnal hypoxemia is only a partial determinant of sleepiness in moderate-to-severe OSA patients.

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